ORIGINAL ARTICLE |
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| Year : 2003 | Volume
: 51
| Issue : 4 | Page : 474--478 |
Role of in vivo proton MR spectroscopy in the evaluation of adult brain lesions: Our preliminary experience
A Kumar, S Kaushik, RP Tripathi, P Kaur, S Khushu
Institute of Nuclear Medicine & Allied Sciences, Brig S. K. Mazumdar Road, Delhi - 110054, India
Correspondence Address:
S Kaushik
NMR Research Centre, Institute of Nuclear Medicine and Allied Sciences, Brig S. K. Mazumdar Road, Delhi - 110054,
India
Context: A definite diagnosis and characterization of intracranial mass lesions, based on structural Magnetic Resonance Imaging (MRI) alone may be difficult. In such cases Proton Magnetic Resonance Spectroscopy (1H-MRS) along with other non-invasive techniques represents an advance in the specificity of brain lesion diagnosis.1 Aims: The primary aim of this study was to evaluate the extent of the utility of 1H-MRS in adult brain tumors and their differentiation from similar-appearing space-occupying lesions. Material and Methods: MRS studies were performed on 1.5 Tesla whole body MR system using standard imaging head coil. Sixty patients (aged 30-65 years), including 35 males (31-65 years) and 25 females (30-65 years) were studied, along with 25 age-matched healthy volunteers (30-64 years). The Student �t� test was used to statistically analyze the spectroscopic data for significant difference in the metabolite ratios of the lesions from normal brain tissue. Results: The Cho/Cr ratio was significantly raised in low and high-grade glioma and meningioma patients (1.85�0.36, 3.50�1.00 and 6.65�2.83 respectively) (mean�standard deviation), as compared with the control group (1.16�0.18); and NAA/Cr and NAA/Cho ratios were found to be lower than normal values in our study (P<0.01). However, in the non-neoplastic lesions, the Cho/Cr ratios were not statistically significant. The tubercular lesions revealed an average Cho/Cr ratio of 1.24�0.18, while it was 1.14�0.07 for infarcts. Conclusions: MR Spectroscopy was useful to arrive at a more definitive diagnosis in doubtful intracranial space-occupying lesions with similar morphological imaging patterns.
How to cite this article:
Kumar A, Kaushik S, Tripathi R P, Kaur P, Khushu S. Role of in vivo proton MR spectroscopy in the evaluation of adult brain lesions: Our preliminary experience.Neurol India 2003;51:474-478
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How to cite this URL:
Kumar A, Kaushik S, Tripathi R P, Kaur P, Khushu S. Role of in vivo proton MR spectroscopy in the evaluation of adult brain lesions: Our preliminary experience. Neurol India [serial online] 2003 [cited 2023 Oct 2 ];51:474-478
Available from: https://www.neurologyindia.com/article.asp?issn=0028-3886;year=2003;volume=51;issue=4;spage=474;epage=478;aulast=Kumar;type=0 |
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