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Year : 2010  |  Volume : 58  |  Issue : 4  |  Page : 585--591

Encephalitis in the clinical spectrum of dengue infection

Aravinthan Varatharaj 
 Neuropathology Group, Department of Clinical Neurology, University of Oxford, United Kingdom

Correspondence Address:
Aravinthan Varatharaj
Pembroke College, Oxford, OX1 1DW
United Kingdom

Dengue viral infections are common worldwide. Clinical manifestations form a broad spectrum, and include uncomplicated dengue fever, dengue hemorrhagic fever, and dengue shock syndrome. Encephalopathy has been well reported and has classically been thought to result from the multisystem derangement that occurs in severe dengue infection; with liver failure, shock, and coagulopathy causing cerebral insult. However, there is increasing evidence for dengue viral neurotropism, suggesting that, in a proportion of cases, there may be an element of direct viral encephalitis. Understanding the pathophysiology of dengue encephalopathy is crucial toward developing a more effective management strategy. This review provides an overview of the clinical spectrum of dengue infection, and examines evidence supporting the existence of dengue encephalitis.

How to cite this article:
Varatharaj A. Encephalitis in the clinical spectrum of dengue infection.Neurol India 2010;58:585-591

How to cite this URL:
Varatharaj A. Encephalitis in the clinical spectrum of dengue infection. Neurol India [serial online] 2010 [cited 2023 Feb 1 ];58:585-591
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