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ORIGINAL ARTICLE
Year : 2014  |  Volume : 62  |  Issue : 1  |  Page : 53--56

Relative quantitative expression of hypoxia-inducible factor 1 alpha messenger ribonucleic acid in recurrent craniopharyngiomas

Hao Liu, Zhiyong Liu, Jin Li, Qiang Li, Chao You, Jianguo Xu 
 Department of Neurosurgery, West China Hospital, Sichuan University, Chengdu, Sichuan, 610041, China

Correspondence Address:
Jianguo Xu
Department of Neurosurgery, West China Hospital, Sichuan University, 37 Guoxue Street, Chengdu, Sichuan, 610041
China

Background: Craniopharyngioma is a benign tumor, but recurrences are common and prognosis is poor. The pathologic mechanism underlying the high recurrence is still unknown. Aims: We hypothesized that there are hypoxic microenvironments within craniopharyngiomas and hypoxia inducible factor-1 alpha (HIF-1α) and its related genes are largely expressed in recurrent craniopharyngiomas. Materials and Methods: A total of 19 patients with craniopharyngiomas have been identified. The relative quantitative expressions of HIF-1α, vascular endothelial growth factor (VEGF) and carbonic adhydrase 9 (CA9) messenger ribonucleic acid (mRNA) of craniopharyngioma tissues were detected by real time reverse transcription polymerase chain reaction. Results: HIF-1α and VEGF mRNA was significantly up-regulated in recurrent craniopharyngiomas. Mean expression levels (recurrent craniopharyngiomas compared with non-recurrent craniopharyngiomas, as normalized to expression of β-actin) were 3.09 versus 0.75 (P = 0.001) for HIF-1α, 1.07 versus 0.32 (P = 0.000) for VEGF, 1.21 versus 1.93 (P = 0.503) for CA9. In craniopharyngiomas, the expression of VEGF showed a significant correlation with HIF-1α (r = 0.836, P = 0.000). Conclusion: There were hypoxic microenvironments within craniopharyngiomas. Therefore, preventing the tumor cells from adapting to the hypoxic conditions may be an effective way to obviate the relapse of craniopharyngioma.


How to cite this article:
Liu H, Liu Z, Li J, Li Q, You C, Xu J. Relative quantitative expression of hypoxia-inducible factor 1 alpha messenger ribonucleic acid in recurrent craniopharyngiomas.Neurol India 2014;62:53-56


How to cite this URL:
Liu H, Liu Z, Li J, Li Q, You C, Xu J. Relative quantitative expression of hypoxia-inducible factor 1 alpha messenger ribonucleic acid in recurrent craniopharyngiomas. Neurol India [serial online] 2014 [cited 2022 Oct 6 ];62:53-56
Available from: https://www.neurologyindia.com/article.asp?issn=0028-3886;year=2014;volume=62;issue=1;spage=53;epage=56;aulast=Liu;type=0