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ORIGINAL ARTICLE
Year : 2019  |  Volume : 67  |  Issue : 6  |  Page : 1469--1471

Differential DNA Methylation Patterns in Patients with Epilepsy due to Malformations of Cortical Development: A Pilot Study

Kuntal Sen1, Rupali Gadkari2, Rajkumar Agarwal2, Senthil Sundaram2 
1 Division of Neurogenetics and Developmental Pediatrics, Children's National Hospital, Washington, DC, USA
2 Division of Genetic, Genomic and Metabolic Disorders, Children's Hospital of Michigan, Wayne State University School of Medicine, Detroit, MI, USA

Correspondence Address:
Dr. Kuntal Sen
Division of Neurogenetics and Developmental Pediatrics, Children's National Hospital, Washington, DC
USA

Objective: To study the DNA methylation profiles in brain tissue of patients with refractory epilepsy due to malformations of cortical development (MCDs). Materials and Methods: Clinical, neuroimaging, and pathology characteristics were defined for 13 patients who underwent resective surgery for epilepsy. Methylation analysis was performed using Illumina® 450k Methylation Microarray. Data analysis was completed, and pathway identification was done using the R/Bioconductor package. Results: Genes associated with Ephrin–Reelin pathway, potassium channels, and glutathione metabolism were differentially methylated in the MCD group when compared with patients who had no evidence of MCD. Conclusions: Our preliminary data reveal that epigenetic pathways may have a role in the pathobiogenesis of MCDs.


How to cite this article:
Sen K, Gadkari R, Agarwal R, Sundaram S. Differential DNA Methylation Patterns in Patients with Epilepsy due to Malformations of Cortical Development: A Pilot Study.Neurol India 2019;67:1469-1471


How to cite this URL:
Sen K, Gadkari R, Agarwal R, Sundaram S. Differential DNA Methylation Patterns in Patients with Epilepsy due to Malformations of Cortical Development: A Pilot Study. Neurol India [serial online] 2019 [cited 2021 Jul 26 ];67:1469-1471
Available from: https://www.neurologyindia.com/article.asp?issn=0028-3886;year=2019;volume=67;issue=6;spage=1469;epage=1471;aulast=Sen;type=0