Neurol India Home 

Year : 2020  |  Volume : 68  |  Issue : 4  |  Page : 916--918

A Case Report of Early Disseminated Lyme Disease

Preema Sinha1, Bhavni Oberoi1, Yadvendra S Sirohi2, Aradhana Sood1, Saikat Bhattacharjee3,  
1 Department of Dermatology, Armed Forces Medical College, Pune, Maharashtra, India
2 Department of Neurology, Armed Forces Medical College, Pune, Maharashtra, India
3 Department of Radiodiagnosis and Imaging, Armed Forces Medical College, Pune, Maharashtra, India

Correspondence Address:
Dr. Preema Sinha
Department of Dermatology, Armed Forces Medical College, Pune - 411 040, Maharashtra


Lyme disease is a multi-organ infectious disease caused by the spirochete “Borrelia burgdorferi,” and transmitted by the “Ixodes” tick. Early disseminated Lyme disease can have varied central nervous system manifestations ranging from meningitis to radiculopathy and cranial neuropathy. If not suspected, misdiagnosis or delayed diagnosis can prove to be fatal. Erythema migrans is the most common clinical presentation, thereby, making dermatological examination extremely crucial in early diagnosis and treatment.

How to cite this article:
Sinha P, Oberoi B, Sirohi YS, Sood A, Bhattacharjee S. A Case Report of Early Disseminated Lyme Disease.Neurol India 2020;68:916-918

How to cite this URL:
Sinha P, Oberoi B, Sirohi YS, Sood A, Bhattacharjee S. A Case Report of Early Disseminated Lyme Disease. Neurol India [serial online] 2020 [cited 2020 Dec 4 ];68:916-918
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Full Text

Lyme disease is a tick-borne multisystem disease which occurs in three stages with protean clinical manifestations depending upon the stage. These include the stage of early localized infection, early disseminated infection, and late infection.[1],[2],[3] Lyme neuroborreliosis can be seen both in the early disseminated and late stages.[4] The classic triad of early disseminated Lyme neuroborreliosis is called meningoradiculoneuropathy, which includes aseptic meningitis, cranial neuropathy, and painful radiculoneuritis occurring in isolation or combination.[4] The most common symptoms reported by such patients include back pain (radiculitis), headache (meningitis), and finally cranial nerve palsy.[5]

Here we present a case of early disseminated Lyme disease where the cutaneous symptoms played a significant role in maintaining a high index of suspicion and reaching an early diagnosis which helped in preventing the potential long-term complications of neuroborreliosis.

 Case Report

A 26-years-old male presented with a red raised progressive circular rash associated with burning and itching of 7 days, fever of 2 days, and severe global headache of 3 days duration. The rash initially started over the inner aspect of his left arm and gradually over the next 2–3 days similar-looking rashes appeared to involve his trunk, left thigh, neck, and left leg [Figure 1] and [Figure 2]. There was no history of any swelling over the body, joint pains, neck stiffness, vomiting, pain abdomen, or chest pain. The patient gave no history of any insect bite or any history of travel in the last 2 months. But due to strong clinical suspicion of Lyme disease in view of his clinical presentation of erythema migrans and endemicity in his area of residence which was near a forest area in Maharashtra, he was thoroughly investigated. A skin biopsy was done which revealed a nonspecific superficial and deep lymphocytic inflammatory infiltrate in the dermis [Figure 3]. Serology was sent for Borrelia antibodies in which Borrelia IgM came out to be raised 3.6 U/mL (>1.1 is positive). The patient was worked up for other systemic involvement including ECG, 2D echocardiography, and nerve conduction studies which were normal.{Figure 1}{Figure 2}{Figure 3}

The patient was clinically, serologically, and histopathologically diagnosed as a case of Lyme disease and managed with Cap doxycycline 100 mg twice daily to which he responded well with a resolution of fever and near resolution of rash in two weeks [Figure 4]. However, despite treatment he had persistent headache, developed low backache and also developed features of meningism for which a non-contrast computed tomography (NCCT) of the head was done which was normal and cerebrospinal fluid (CSF) analysis was done which revealed a protein count of 170 mg/dL (increased), sugar level was 59 mg/dL, and lymphocyte count was 110 (suggestive of aseptic meningitis), CSF Borrelia antibodies were, however, negative. The patient was managed for neuroborreliosis with injection ceftriaxone for 14 days to which he responded well with near resolution of headache and backache. The patient has been kept under follow-up for any systemic complications or further manifestations of chronic Lyme disease.{Figure 4}


Lyme neuroborreliosis can present with Lyme meningitis, myelopathies, radiculopathies, and late neurologic Lyme disease.[6] If untreated, these patients might go on to develop progressive encephalomyelitis or cerebrovascular neuroborreliosis, which can lead to parenchymal or meningovascular involvement.[7] The criteria for Lyme neuroborreliosis include neurological symptoms, CSF pleocytosis, and Borrelia-specific antibodies intrathecally. All three are a definite diagnosis while two out of three give a probable diagnosis.[8] The intrathecal production of antibodies is the gold standard but has very low sensitivity in the early stages. The CSF in Lyme's meningitis generally presents with mononuclear cell predominance, a high level of proteins, and nearly normal sugar; hypoglycorrhachia, a rare feature has been reported in the case report by Farmania et al.[8] Patients with central nervous system manifestations should be treated with parenteral ceftriaxone (2 g daily) for 14 days and with late involvement for three weeks.[9]

The dermatological manifestations provide great help in providing a diagnostic clue and the typical erythema migrans present in almost 40–60% of the patients is usually sufficient to make a diagnosis in the absence of a corroboratory laboratory test.[10] The rash is generally of two types, either an expansive lesion with various hues of erythema or a target-like lesion. The surface is smooth and the lesion may be associated with burning sensation or pain. Centers for Disease Control and Prevention (CDC) guidelines state that the diameter of the rash must be at least 5 cm to qualify as erythema migrans, however, in special clinical situations, smaller lesions may be considered.[11] In our patient, the skin manifestations played a pivotal role in the initial diagnosis of the patient and the case also highlights the importance of knowing the complications and sequelae of the disease which prompted us to further evaluate and manage the patient on the lines of neuroborreliosis.

Declaration of patient consent

The authors certify that they have obtained all appropriate patient consent forms. In the form, the patient(s) has/have given his/her/their consent for his/her/their images and other clinical information to be reported in the journal. The patients understand that their names and initials will not be published and due efforts will be made to conceal their identity, but anonymity cannot be guaranteed.

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Conflicts of interest

There are no conflicts of interest.


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