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ORIGINAL ARTICLE
Year : 2021  |  Volume : 69  |  Issue : 2  |  Page : 369--375

Utility of Serial Nerve Conduction Studies in the Electrodiagnosis of Guillain–Barre Syndrome

Arun Mathai Mani1, Appaswamy Thirumal Prabhakar1, PT Alexander1, Aditya Nair1, Asish Vijayaraghavan1, Atif Shaikh1, Rohit Benjamin1, Ajith Sivadasan1, Vivek Mathew1, Sanjith Aaron1, Mathew Alexander2 
1 Neurology Unit, Department of Neurological Sciences, Christian Medical College, Vellore, Tamil Nadu, India
2 The Brunei Neuroscience Stroke and Rehabilitation Centre, India

Correspondence Address:
Mathew Alexander
The Brunei Neuroscience Stroke and Rehabilitation Centre, Brunei; Former Head of Neurology, Christian Medical College Vellore - 632 004, Tamil Nadu, India
India

Background: Guillain–Barre syndrome can be electrophysiologically classified into demyelinating and axonal subtypes and nerve conduction studies remain the mainstay in electrodiagnosis. Accurate electrodiagnosis has both therapeutic and prognostic significance and different criteria sets have been proposed for classification. Objectives: To electrophysiologically classify GBS patients into AIDP and axonal subtypes according to various published criteria (Cornblath, 1990: Hadden, 1998, Rajabally, 2015), investigate if serial NCS changes the classification, and to identify additional parameters which may support the electrodiagnosis. Materials and Methods: In a retrospective study, we included all patients aged 15 to 80 years, admitted with a diagnosis of GBS between August 2015 and July 2017, who had at least two serial NCS. The various published criteria were applied to the two serial NCS and subtype classification along with diagnostic shifts on serial NCS were ascertained. Results: At the first test, the established criteria gave a yield of 45.2% to 71% for AIDP, while 29% to 54.8% of patients were classified as axonal GBS. In the second study, there was a change in electrodiagnosis, ranging from 9.6% to 16.1%. The resolution of reversible conduction failure and misclassification of subtypes were the major reason for diagnostic shifts. Sural sparing pattern, facial nerve dysfunction, abnormal blink reflex, and phrenic nerve dysfunction were more common in AIDP. Conclusions: Serial nerve conduction studies allow an accurate electrodiagnosis of GBS subtypes, which has both therapeutic and prognostic implications. Also, the use of additional parameters such as blink reflex facial and phrenic nerve conduction may supplement routine NCS.


How to cite this article:
Mani AM, Prabhakar AT, Alexander P T, Nair A, Vijayaraghavan A, Shaikh A, Benjamin R, Sivadasan A, Mathew V, Aaron S, Alexander M. Utility of Serial Nerve Conduction Studies in the Electrodiagnosis of Guillain–Barre Syndrome.Neurol India 2021;69:369-375


How to cite this URL:
Mani AM, Prabhakar AT, Alexander P T, Nair A, Vijayaraghavan A, Shaikh A, Benjamin R, Sivadasan A, Mathew V, Aaron S, Alexander M. Utility of Serial Nerve Conduction Studies in the Electrodiagnosis of Guillain–Barre Syndrome. Neurol India [serial online] 2021 [cited 2021 Jun 23 ];69:369-375
Available from: https://www.neurologyindia.com/article.asp?issn=0028-3886;year=2021;volume=69;issue=2;spage=369;epage=375;aulast=Mani;type=0