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Year : 2021  |  Volume : 69  |  Issue : 2  |  Page : 461--465

Mitochondrial DNA Haplogroups and Three Independent Polymorphisms have no Association with the Risk of Parkinson's Disease in East Indian Population

Tania Saha1, Somrita Roy1, Rajashree Chakraborty1, Arindam Biswas2, Shyamal K Das3, Kunal Ray4, Jharna Ray2, Mainak Sengupta1 
1 Department of Genetics, University of Calcutta, Kolkata, West Bengal, India
2 S. N. Pradhan Centre for Neurosciences, University of Calcutta, Kolkata, West Bengal, India
3 Movement Disorders Clinic, Bangur Institute of Neurosciences, Kolkata, West Bengal, India
4 School of Biological Sciences, RKMVERI, Narendrapur, West Bengal, India

Correspondence Address:
Dr. Mainak Sengupta
35, Ballygunge Circular Road, Kolkata - 700 019
India

Background: Parkinson's disease (PD) is a multifaceted illness affecting ~ 0.3% of the world population. The genetic complexity of PD has not been, fully elucidated. Several studies suggest that mitochondrial DNA variants are associated with PD. Objective: Here, we have explored the possibility of genetic association between mitochondrial haplogroups as well as three independent SNPs with PD in a representative east Indian population. Methods and Material: The Asian mtDNA haplogroups: M, N, R, B, D, M7, and 3 other SNPs: 4336 T/C, 9055 G/A, 13708 G/A were genotyped in 100 sporadic PD patients and 100 matched controls via conventional PCR-RFLP-sequencing approach. Results: The distribution of mtDNA haplogroups, as well as 3 single polymorphisms, did not show any significant differences (P > 0.05) between patients and controls. Conclusion: This is the first of its kind of study from India that suggests no association of selected mitochondrial DNA variations with PD.


How to cite this article:
Saha T, Roy S, Chakraborty R, Biswas A, Das SK, Ray K, Ray J, Sengupta M. Mitochondrial DNA Haplogroups and Three Independent Polymorphisms have no Association with the Risk of Parkinson's Disease in East Indian Population.Neurol India 2021;69:461-465


How to cite this URL:
Saha T, Roy S, Chakraborty R, Biswas A, Das SK, Ray K, Ray J, Sengupta M. Mitochondrial DNA Haplogroups and Three Independent Polymorphisms have no Association with the Risk of Parkinson's Disease in East Indian Population. Neurol India [serial online] 2021 [cited 2021 Jun 21 ];69:461-465
Available from: https://www.neurologyindia.com/article.asp?issn=0028-3886;year=2021;volume=69;issue=2;spage=461;epage=465;aulast=Saha;type=0