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Year : 2022  |  Volume : 70  |  Issue : 2  |  Page : 822--823

Cerebral Cavernous Malformations Confined in the Cerebral Sulci

Satoshi Tsutsumi1, Ikuko Ogino2, Akihide Kondo2, Hisato Ishii1,  
1 Departments of Neurological Surgery, Juntendo University Urayasu Hospital, Urayasu, Chiba
2 Department of Neurological Surgery, Juntendo University School of Medicine, Bunkyo-Ku, Tokyo, Japan

Correspondence Address:
Dr. Satoshi Tsutsumi
Department of Neurological Surgery, Juntendo University Urayasu Hospital, 2-1-1 Tomioka, Urayasu - 279-0021, Chiba
Chiba




How to cite this article:
Tsutsumi S, Ogino I, Kondo A, Ishii H. Cerebral Cavernous Malformations Confined in the Cerebral Sulci.Neurol India 2022;70:822-823


How to cite this URL:
Tsutsumi S, Ogino I, Kondo A, Ishii H. Cerebral Cavernous Malformations Confined in the Cerebral Sulci. Neurol India [serial online] 2022 [cited 2022 Aug 8 ];70:822-823
Available from: https://www.neurologyindia.com/text.asp?2022/70/2/822/344604


Full Text



Cerebral cavernous malformations (CCMs) are hamartomatous vascular anomalies occurring in the central nervous system. A fraction of CCMs shows familiar forms.[1] On neuroimages, a CCM typically exhibits a well-circumscribed, parenchymal lesion accompanying hemorrhage and iron deposition.[2] A 29-year-old woman was transported to the Emergency Department sustaining a generalized seizure. Cerebral magnetic resonance imaging (MRI) revealed multiple lesions in the cerebral hemispheres and brainstem. They appeared isointense on gradient-echo sequence and hypointensity on T2-weighted imaging. Some of them were located in the cerebral sulci, instead of the parenchyma. They lacked perilesional hemosiderin deposits or brain edema. Besides, cerebral edema was noted in the left temporal lobe [Figure 1]a, [Figure 1]b, [Figure 1]c, [Figure 1]d, [Figure 1]e, [Figure 1]f, [Figure 1]g. Based on the radiological appearance, familial CCMs were assumed. The patient underwent genomic analysis as a previous investigation.[1] The procedure identified a CCM1 (KRIT1) missense variant (c. 470T > C; p.Leu157Ser). Oral administration of levetiracetam was started with satisfactory control of the patient's seizure. The MRI performed 9 months later revealed stable appearance of lesions in the cerebral sulci andregression of the cerebral edema [Figure 1h]. To our knowledge, there is no study documenting CCMs confined in the cerebral sulci. The unusual locations outside the brain parenchyma can be, at least partly, explained by the nature of the CCM1 that causes abnormal angioproliferation in any part of the brain. In addition, the vascular permeability of CCMs is suggested to correlate with the disease activities.[3] These two factors might have contributed to the unusual formation of CCMs in the cerebral sulci and its unique clinical appearance.{Figure 1}

Ethical approval

We declare that the present study has been approved by the institution's guidelines for human research, and performed in accordance with the ethical standards laid down in the 1964 Declaration of Helsinki and its later amendments.

Declaration of patient consent

We declare that the presented patient gave informed consent prior to inclusion in this study.

Financial support and sponsorship

Nil.

Conflicts of interest

There are no conflicts of interest.

References

1Tsutsumi S, Ogino I, Miyajima M, Ikeda T, Shindo N, Yasumoto Y, et al. Genomic causes of multiple cerebral cavernous malformations in a Japanese population. J Clin Neurosci 2013;20:667-9.
2Gross BA, Lin N, Du R, Day AL. The natural history of intracranial cavernous malformations. Neurosurg Focus 2011;30:E24.
3Mikati AG, Khanna O, Zhang L, Girard R, Shenkar R, Guo X, et al. Vascular permeability in cerebral cavernous malformations. J Cereb Blood Flow Metab 2015;35:1632-9.