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Figure 4: Generation of ROS is involved in IDH1-R132H-induced increase of HIF-1α expression in glioblastoma cells.(a) ROS determination in U87 and U251 cells transfected with IDH1-WT or IDH1-R132H. (b) Relative mRNA expression in U87 and U251 cells transfected with IDH1-WT or IDH1-R132H. (c) Protein expression of HIF-1α in U87 and U251 cells transfected with IDH1-WT or IDH1-R132H and treated with NAC. * P < 0.05

Figure 4: Generation of ROS is involved in IDH1-R132H-induced increase of HIF-1α expression in glioblastoma cells.(a) ROS determination in U87 and U251 cells transfected with IDH1-WT or IDH1-R132H. (b) Relative mRNA expression in U87 and U251 cells transfected with IDH1-WT or IDH1-R132H. (c) Protein expression of HIF-1α in U87 and U251 cells transfected with IDH1-WT or IDH1-R132H and treated with NAC. * <i>P</i> < 0.05