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Figure 5: Increased expression of FAT1 is involved in IDH1-R132H-induced inhibition of glioblastoma malignancy. (a) Protein expression of FAT1 in U87 and U251 cells transfected with IDH1-WT or IDH1-R132H. (b) Protein expression of FAT1 and HIF-1α in U87 and U251 cells transfected with shFAT1 or shNC. (c) Proliferation of U87 and U251 cells transfected with IDH1-WT or IDH1-R132H, and shFAT1 or shNC. (d) Apoptosis of U87 and U251 cells transfected with IDH1-WT or IDH1-R132H, and shFAT1 or shNC, in the presence or absence of TMZ. (e) ROS determination in U87 and U251 cells transfected with IDH1-WT or IDH1-R132H, and shFAT1. **P < 0.01

Figure 5: Increased expression of FAT1 is involved in IDH1-R132H-induced inhibition of glioblastoma malignancy. (a) Protein expression of FAT1 in U87 and U251 cells transfected with IDH1-WT or IDH1-R132H. (b) Protein expression of FAT1 and HIF-1α in U87 and U251 cells transfected with shFAT1 or shNC. (c) Proliferation of U87 and U251 cells transfected with IDH1-WT or IDH1-R132H, and shFAT1 or shNC. (d) Apoptosis of U87 and U251 cells transfected with IDH1-WT or IDH1-R132H, and shFAT1 or shNC, in the presence or absence of TMZ. (e) ROS determination in U87 and U251 cells transfected with IDH1-WT or IDH1-R132H, and shFAT1. **<i>P</i> < 0.01