Figure 1 :(a) Coronal slice of the brain, from a case of Wilson’s disease shows bilaterally symmetrical putaminal (P) softening (arrows) extending laterally up to the external capsule; (b) Whole mount preparation stained with Luxol Fast Blue shows relative preservation of internal capsule and pale and softened neuropil in the putamen (P, arrow). LFB  4; (c) Softened area in the putamen has bizarre astrocytes with vesicular lobulated nuclei (arrow) with inset showing Alzheimer type 2 astrocytes in the neuropil (arrow). H and E,  240, Inset: H and E,  300; (d) Large opalski cell characteristic of Wilson’s disease has irregular eosinophilic cytoplasm and small peripherally placed pyknotic nucleus. H and E,  240; (e) Slice of enlarged liver shows microand macronodular cirrhosis. Inset demonstrates copper deposits within hepatocytes on rubeanic acid stain. Inset: Rubeanic acid  240