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Figure 1 :Signal-intensity time curve used to generate perfusion-weighted images. Peak intensity is proportional to cerebral blood fl ow, area under the curve to cerebral blood volume. Mean transit time is calculated as CBV/CBF. Diffusion-weighted image demonstrates the infarct core. The volume of tissue that is hypoperfused, but outside the infarct core can be used as an operational defi nition of the ischemic penumbra. Penumbral tissue volume estimates vary with the PWI parameter utilized and the threshold used to differentiate at risk tissue from benign oligemia

Figure 1 :Signal-intensity time curve used to generate perfusion-weighted images. Peak intensity is proportional to cerebral blood fl ow, area under the curve to cerebral blood volume. Mean transit time is calculated as CBV/CBF. Diffusion-weighted image demonstrates the infarct core. The volume of
tissue that is hypoperfused, but outside the infarct core can be used as an operational defi nition of the ischemic penumbra. Penumbral tissue volume estimates vary with the PWI parameter utilized and the threshold used to differentiate at risk tissue from benign oligemia