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Figure 3: Shows expression of markers of tumor aggressiveness in CCA. Occasional tumor cell nuclei are labeled by MIB-1, (a) anti-topoisomerase-2 alpha, (b) while more cells show p53 labeling. (c) A diffuse immunopositivity is seen for p27 (d) and MGMT. (e) All figures are original magnification ×160. (f) Shows ultrastructural characteristics of Crooke's hyaline. Numerous perinuclear intermediate filaments are seen obscuring rough ER and golgi bodies, displacing the secretory granules peripherally. Original magnification ×9300. CCA = Crooke's cell adenomas, ER = Endoplasmic reticulum

Figure 3: Shows expression of markers of tumor aggressiveness in CCA. Occasional tumor cell nuclei are labeled by MIB-1, (a) anti-topoisomerase-2 alpha, (b) while more cells show p53 labeling. (c) A diffuse immunopositivity is seen for p27 (d) and MGMT. (e) All figures are original magnification ×160. (f) Shows ultrastructural characteristics of Crooke's hyaline. Numerous perinuclear intermediate filaments are seen obscuring rough ER and golgi bodies, displacing the secretory granules peripherally. Original magnification ×9300. CCA = Crooke's cell adenomas, ER = Endoplasmic reticulum