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Figure 2: Brain biopsy comprising of white matter fragments showing rarefaction and infiltration by foamy histiocytes (a, hematoxylin and eosin, ×200), perivascular lymphocytic infiltrate (b, hematoxylin and eosin, ×200), reactive astrocytes (c, hematoxylin and eosin, ×400), and oligodendroglial cells with nuclear enlargement and basophilic viral inclusions (d, hematoxylin and eosin, ×400). Inset in d shows immunopositivity for SV-40 antigen in oligodendrocytes with viral inclusions (immunohistochemistry, ×200)

Figure 2: Brain biopsy comprising of white matter fragments showing rarefaction and infiltration by foamy histiocytes (a, hematoxylin and eosin, ×200), perivascular lymphocytic infiltrate (b, hematoxylin and eosin, ×200), reactive astrocytes (c, hematoxylin and eosin, ×400), and oligodendroglial cells with nuclear enlargement and basophilic viral inclusions (d, hematoxylin and eosin, ×400). Inset in d shows immunopositivity for SV-40 antigen in oligodendrocytes with viral inclusions (immunohistochemistry, ×200)