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Figure 2: Pathogenesis in 17 alpha-hydroxylase deficiency (17OHD). The blockage at the 17α-OH impairs cortisol and sex steroid synthesis. The low cortisol increases adrenocorticotropic hormone production. Accumulated deoxycorticosterone and corticosterone cause plasma volume expansion, hypertension and hypokalemia, which suppress renin and aldosterone

Figure 2: Pathogenesis in 17 alpha-hydroxylase deficiency (17OHD). The blockage at the 17α-OH impairs cortisol and sex steroid synthesis. The low cortisol increases adrenocorticotropic hormone production. Accumulated deoxycorticosterone and corticosterone cause plasma volume expansion, hypertension and hypokalemia, which suppress renin and aldosterone