Neurol India Close
 

Figure 1: Schematic of genetic factors involved in clinical manifestations of AD-DS in which are described the events of pathogenesis DS-AD (light gray box) and the interaction of genes inside (medium-dark gray box) and outside (dark gray box) of chromosome 21 with the neurologic phenotypes and clinical aspects (white box): human chromosome 21 (HSA21); Down syndrome (DS); beta amyloid protein (Aβ); amyloid precursor protein (APP); apolipoprotein E (APOE); lipid transporter ATP-binding cassette G1 (ABCG1); beta-secretase 1 (BACE1) beta-secretase 2 (BACE2); microRNA 155 (Mir-155); ETS proto-oncogene 2, transcription factor (ETS2); Presenilin 1 (PSEN 1); Presenilin 2 (PSEN 2); dual-specificity tyrosine-phosphorylation-regulated kinase 1A (Dyrk1A); small ubiquitin-related modifier 3 (SUMO3); cystatin C (CST3); coxsackie virus and adenovirus receptor (CXADR); regulator of regulate calcineurin 1 (RCAN1); microtubule affinity-regulating kinase 4 (MARK4); ADAM metalloproteinase with thrombospondin type 1 motif, 1 (ADAMTS1); ADAM metalloproteinase with thrombospondin type 1 motif, 5 (ADAMTS5); S100 calcium binding protein astrocyte-derived (S100B); superoxide-dismutase type 1 (SOD-1); runt-related transcription factor 1 (RUNX1) genes

Figure 1: Schematic of genetic factors involved in clinical manifestations of AD-DS in which are described the events of pathogenesis DS-AD (light gray box) and the interaction of genes inside (medium-dark gray box) and outside (dark gray box) of chromosome 21 with the neurologic phenotypes and clinical aspects (white box): human chromosome 21 (HSA21); Down syndrome (DS); beta amyloid protein (Aβ); amyloid precursor protein (<i>APP</i>); apolipoprotein E (<i>APOE</i>); lipid transporter ATP-binding cassette G1 (<i>ABCG1</i>); beta-secretase 1 (<i>BACE1</i>) beta-secretase 2 (<i>BACE2</i>); microRNA 155 (<i>Mir-155</i>); ETS proto-oncogene 2, transcription factor (<i>ETS2</i>); Presenilin 1 (<i>PSEN</i> 1); Presenilin 2 (<i>PSEN 2</i>); dual-specificity tyrosine-phosphorylation-regulated kinase 1A (<i>Dyrk1A</i>); small ubiquitin-related modifier 3 (SUMO3); cystatin C (<i>CST3</i>); coxsackie virus and adenovirus receptor (CXADR); regulator of regulate calcineurin 1 (<i>RCAN1</i>); microtubule affinity-regulating kinase 4 (<i>MARK4</i>); ADAM metalloproteinase with thrombospondin type 1 motif, 1 (<i>ADAMTS1</i>); ADAM metalloproteinase with thrombospondin type 1 motif, 5 (<i>ADAMTS5</i>); S100 calcium binding protein astrocyte-derived (<i>S100B</i>); superoxide-dismutase type 1 (<i>SOD-1</i>); runt-related transcription factor 1 (<i>RUNX1</i>) genes