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Figure 2: Histological features of brain biopsy specimens from the right corpus callosum. Hematoxylin and eosin staining showed angiocentric lymphocytic infiltrates and formed perivascular cuffing (a and b). The perivascular infiltrates were predominantly CD3-positive T lymphocytes (c), followed by CD20-positive B lymphocytes (d). EBV-encoded RNA in situ hybridization showed negative (e). Bars indicate 100 (b and e), 200 (a and c), or 400 μm (d)

Figure 2: Histological features of brain biopsy specimens from the right corpus callosum. Hematoxylin and eosin staining showed angiocentric lymphocytic infiltrates and formed perivascular cuffing (a and b). The perivascular infiltrates were predominantly CD3-positive T lymphocytes (c), followed by CD20-positive B lymphocytes (d). EBV-encoded RNA <i>in situ</i> hybridization showed negative (e). Bars indicate 100 (b and e), 200 (a and c), or 400 μm (d)